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KMID : 1123920150290010039
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Korean Journal of Oriental Physiology and Pathology
2015 Volume.29 No. 1 p.39 ~ p.45
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Effects of Added Chongmyung-tang on Behavior and Molecular Factors in the Alzheimer's Disease Model
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Kim Kook-Ki
Choi Woo-Chang
Kim Seung-Hyung
Namgung Uk
Park Yang-Chun
Kang Wee-Chang
Lee Sang-Ryong
Jung In-Chul
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Abstract
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This experiment was designed to investigate the effect of Added Chongmyung-tang (ACM) on Alzheimer"s disease mouse model. Effects of ACM on learning behavior were investigated using the Morris water maze method. Expression levels of molecular factors related to Alzheimer"s disease such as glial fibrillary acidic protein (GFAP), cluster of differentiation antigen 68 (CD68), and tau protein in the hippocampus of APP-SWE Tg2576 mice were analyzed by immunofluorescence staining method. ACM reduced escape latency in the Morris water maze test. ACM decreased the expression level of GFAP and tau protein in the hippocampus. These results suggest that ACM may be involved in regulating molecules that are known to play an important role in the pathogenesis of Alzheimer"s disease.
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KEYWORD
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ACM, Dementia, Alzheimer disease
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